Current understanding of the neuropathophysiology of pain in chronic pancreatitis

作     者：Amporn Atsawarungruangkit Supot Pongprasobchai 

作者机构：Department of Family MedicineRajavithi Hospital Division of Gastroenterology Depart-ment of MedicineSiriraj Hospital 

出 版 物：《World Journal of Gastrointestinal Pathophysiology》 (世界胃肠病理生理学杂志（英文版）（电子版）)

年 卷 期：2015年第6卷第4期

页      面：193-202页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Neurobiology Neuropathophysiology Pain Pancreatic 

摘      要：Chronic pancreatitis(CP) is a chronic inflammatory disease of the pancreas. The main symptom of patients with CP is chronic and severe abdominal pain. However, the pathophysiology of pain in CP remains ***, researchers believed that the pain was caused by anatomical changes in pancreatic structure. However, treatment outcomes based on such beliefs are considered unsatisfactory. The emerging explanations of pain in CP are trending toward neurobiological theories. This article aims to review current evidence regarding the neuropathophysiology of pain in CP and its potential implications for the development of new treatments for pain in CP.