Expression of Vascular Endothelial Growth Factor in Hepatocellular Carcinoma and Its Relationship to Tumor Growth and Metastasis

作     者：郑世曦 武忠弼 阮幼冰 汤健 ZHENG Shixi;WU Zhongbi;RUAN Youbing(Department of Ultrastructural Pathology, Research Center of Experimental Medicine, Tongji Medical University, Wuhan 430030)TANG Jian (Institute of Cardiovascular Research, Beijing Medical University, Beijing 100000)

作者机构：Department of Ultrastructural Pathology Research Center of Experimental Medicine Tongji Medical University Wuhan Institute of Cardiovascular Research Beijing Medical University Beijing 

出 版 物：《Journal of Huazhong University of Science and Technology(Medical Sciences)》 (华中科技大学学报（医学英德文版）)

年 卷 期：1998年第18卷第1期

页      面：10-12页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100104[医学-病理学与病理生理学] 10[医学] 

主　　题：vascular endothelial growth factor hepatocellular carcinoma metastasis 

摘      要：To understand the relationship between the expression of vasCular endothelial growth factor (VEGF) and the growth, metastasis of hepatocellular car cinoma (HCC), immunohistochemistry and Northern blot were used to investigate VEGF protein and mRNA in 21 cases of HCC with and without *** protein was found in 8 of 9 cases with metastasis, whereas only in 4 of 12 cases without rnetastasis. The Positive rate of the former was significantly higher than that in the latter. VEGF mRNA was detectable in both carcinoma and its surrounding liver tissues, but its level in the former was 2 - 3 times higher than that in the latter. In carcinoma with metastasis, the mRNA level was 5-6 times higher than that without metastasis. It is concluded that VEGF Is closely related to the growth of HCC as well as its metastasis and it might be a useful indicator for the metastatic potential of HCC.