Small ubiquitin-like modifier protein-specific protease 1 and prostate cancer

作     者：Yong Zuo Jin-Ke Cheng 

作者机构：Laboratory for Cell Signal Transduction Institute of Medical Sciences Shanghai Jiao Tong University School ofMedicine Shanghai 200025 China 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2009年第11卷第1期

页      面：36-38页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Studies in the author's laboratory were funded by startup funds from the Shanghai Jiao Tong University School of Medicine  National Natural Science Foundation of China (No. 30772462). Most of the work described in this review was performed in Dr Edward Yeh's laboratory at the MD Anderson Cancer Center  Houston  TX  USA 

主　　题：SUMO SUMO-specific protease prostate cancer androgen receptor HIF 1α 

摘      要：Small ubiquitin-like modifier protein （SUMO） modification is a highly dynamic process, catalyzed by SUMO- specific activating （El）, conjugating （E2） and ligating （E3） enzymes, and reversed by a family of SUMO-specific proteases （SENPs）. There are six members of the human SENP family, and each SENP has different cellular locations and substrate specificities. However, the precise roles of SENPs in cellular processes have not been elucidated to date. This brief review will focus on recent advances pertaining to the identified targets of SENP 1 and its potential role in prostate cancer.