[bmim]OH： An efficient catalyst for the synthesis of mono and bis spirooxindole derivatives in ethanol at room temperature

作     者：Swapnil A. Padvi Yogesh A. Tayade Yogesh B. Wagh Dipak S. Dalai 

作者机构：School of Chemical Sciences North Maharashtra University Jalgaon 425 001 MS India 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2016年第27卷第5期

页      面：714-720页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：University Grants Commission  UGC 

主　　题：Task specific ionic liquid [bmim]OH lsatin Spiro compounds Green synthesis 

摘      要：A rapid and efficient, one pot synthesis of spirooxindole derivatives has been attempted by three- component reaction of isatin, malononitrile and carbonyl compound possessing a reactive c^-methylene group by using task specific ionic liquid, 1-butyl-3-methyl imidazolium hydroxide [bmim]OH as a catalyst. The important features of this methodology are straight forward route in short reaction time at room temperature and avoid any hazardous organic solvent, toxic catalyst, tedious purification step. Interestingly, this protocol is not only limited to mono-systems but also to the synthesis of newer bis- spirooxindole system. The separation of the product and reusability of the catalyst are easy with excellent yield. The [bmim]OH catalyst system could be reused up to five recycles without appreciable loss of activity.