Recent developments in palliative chemotherapy for locally advanced and metastatic pancreas cancer
Recent developments in palliative chemotherapy for locally advanced and metastatic pancreas cancer作者机构：Division of Hematology/OncologySylvester Comprehensive Cancer CenterUniversity of Miami
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2010年第16卷第6期
页 面：673-682页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Adjuvant therapy Chemotherapy Palliative therapy Pancreas cancer Radiotherapy
摘 要：In spite of advances made in the management of the other more common cancers of the gastrointestinal tract,significant progress in the treatment of pancreatic cancer remains *** as many deaths occur from pancreatic cancer as are diagnosed each year reflecting the poor prognosis typically associated with this *** recently,the only treatment with an impact on survival was *** the palliative setting,gemcitabine(Gem) has been a standard treatment for advanced pancreatic cancer since it was shown a decade ago to result in a superior clinical benefit response and survival compared with bolus *** then,clinical trials have explored the pharmacokinetic modulation of Gem by fixed dose administration and the combination of Gem with other cytotoxic or the biologicallytargeted***,promising trial results in small phaseⅡtrials have not translated into survival improvements in larger phaseⅢrandomized trials in the advanced disease *** trials have recently reported modest survival improvements with the use of combination treatment with Gem and capecitabine(United Kingdom National Cancer Research GEMCAP trial) or erlotinib(National Cancer Institute of CanadaClinical Trials Group PA.3 trial) .This review will focus on the use of systemic therapy for advanced and metastatic pancreatic cancer,summarizing the results of several recent clinical trials and discuss their implications for clinical *** will also discuss briefly the second-line chemotherapy options for advanced pancreatic cancer.
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