G-protein-coupled estrogen receptor as a new therapeutic target for treating coronary artery disease

作     者：Guichun Han Richard E White 

作者机构：Women’s Health DivisionMichael E DeBakey InstituteDepartment of Physiology and PharmacologyCollege of Veterinary Medicine and Biomedical SciencesTexas A and M UniversityCollege StationTX 77843United States Department of Biomedical SciencesGeorgia Campus-Philadelphia College of Osteopathic MedicineSuwaneeGA 30024United States 

出 版 物：《World Journal of Cardiology》 (世界心脏病学杂志（英文版）（电子版）)

年 卷 期：2014年第6卷第6期

页      面：367-375页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by The American Heart Association,Texas Affiliate,No.7370061 the Center for Chronic Disorders of Aging,PCOM 

主　　题：G-protein-coupled estrogen receptor Coronary arteries G-1 Atherosclerosis Estrogen 

摘      要：Coronary heart disease(CHD) continues to be the greatest mortality risk factor in the developed world. Estrogens are recognized to have great therapeutic potential to treat CHD and other cardiovascular diseases; however,a significant array of potentially debilitating side effects continues to limit their use. Moreover,recent clinical trials have indicated that long-term postmenopausal estrogen therapy may actually be detrimental to cardiovascular health. An exciting new development is the finding that the more recently discovered G-protein-coupled estrogen receptor(GPER) is expressed in coronary arteries-both in coronary endothelium and in smooth muscle within the vascular wall. Accumulating evidence indicates that GPER activation dilates coronary arteries and can also inhibit the prolif-eration and migration of coronary smooth muscle cells. Thus,selective GPER activation has the potential to increase coronary blood flow and possibly limit the debilitating consequences of coronary atherosclerotic disease. This review will highlight what is currently known regarding the impact of GPER activation on coronary arteries and the potential signaling mechanisms stimulated by GPER agonists in these vessels. A thorough understanding of GPER function in coronary arteries may promote the development of new therapies that would help alleviate CHD,while limiting the potentially dangerous side effects of estrogen therapy.