2例多囊卵巢综合征妇女应用甲福明相关的多胎妊娠病例报道及文献回顾

作     者：Boothroyd C. Yazdani A. 张旸 

作者机构：Greenslopes Specialist Centre 25/121 Newdegate St Brisbane QLD 4120 Australia 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2006年第2卷第4期

页      面：34-35页

学科分类：1002[医学-临床医学] 100211[医学-妇产科学] 10[医学] 

主　　题：多囊卵巢综合征 多胎妊娠 甲福明 文献回顾 诱导排卵 克罗米芬 治疗周期 膜性 首次治疗 

摘      要：Objective: To describe the first reported cases of two women with polycystic ovary syndrome (PCOS) desirous of pregnancy who conceived trichorionic pregnancies following ovulation induction with metformin alone and metformin plus clomiphene. Design: Case report. Setting: Private fertility practice. Patient(s): Two women with polycystic ovary syndrome, one lean and one overweight, both oligoovulatory and not undertaking their first cycle of treatment. Intervention(s): Ovulation induction by metformin alone or in combination with clomiphene. Main Outcome Measure(s): Higher-order multiple pregnancy (triplet or greater). Result(s): Two cases of trichorionic pregnancy. Conclusion(s): This is the first report of higher-order multiple pregnancies resulting from the use of either metformin alone or in combination with clomiphene. The additive effects of adjunctive treatments such as weight reduction, ovarian drilling, and clomiphene and metformin therapy may result in an increased incidence of higher-order multiple pregnancy and women need to be counseled about this risk. Further research is required to quantify the risk of this event per treatment cycle.