Influence of apolipoprotein E and its receptors on cerebral amyloid precursor protein metabolism following traumatic brain injury

作     者：ZHOU Shuai SUN Xiao-chuan 

作者机构：Department of Neurosurgery First Affiliated Hospital of Chongqing Medical University Chongqing 400016China 

出 版 物：《Chinese Journal of Traumatology》 (中华创伤杂志（英文版）)

年 卷 期：2012年第15卷第3期

页      面：183-187页

学科分类：0403[教育学-体育学] 1002[医学-临床医学] 10[医学] 

基　　金：National Natural Science Foundation of China  NSFC  (30973087) 

主　　题：Apolipoproteins E Amyloid beta-protein precursor Brain injuries 

摘      要：Abstract：Traumatic brain injury (TBI) is the leading cause of mortality and disability among young individuals in our society,and globally the incidence of TBI is rising sharply.Mounting evidence has indicated that apolipoprotein E (apoE:protein; APOE:gene) genotype influences the outcome after TBI.The proposed mechanism by which APOE affects the clinicopathological consequences of TBI is multifactorial and includes amyloid deposition,disruption of lipid distribution,dysfunction of mitochondrial energy production,oxidative stress and increases intracellular calcium in response to injury.This paper reviews the current state of knowledge regarding the influence of apoE and its receptors on cerebral amyloid betaprotein precursor metabolism following TBI。