Proton therapy in clinical practice

作     者：Hui Liu Joe Y. Chang 

作者机构：Sun Yat-sen University Cancer Center Guangzhou Guangdong 510060 P. R. China Radiation Oncology Department University of Texas MD Anderson Cancer Center Houston TX 77030 USA 

出 版 物：《Chinese Journal of Cancer》 (CHINESE JOURNAL OF CANCER)

年 卷 期：2011年第30卷第5期

页      面：315-326页

核心收录：

学科分类：090601[农学-基础兽医学] 070207[理学-光学] 1002[医学-临床医学] 07[理学] 09[农学] 0906[农学-兽医学] 0702[理学-物理学] 

基　　金：AZA Conservation Endowment Fund Disney’s Animal Programs Minnesota Zoo Conservation Fund Wildlife Conservation Network 

主　　题：质子束 临床实践 治疗 Bragg峰 辐射剂量 物理特性 局部控制 癌症病人 

摘      要：Radiation dose escalation and acceleration improves local control but also increases toxicity.Proton radiation is an emerging therapy for localized cancers that is being sought with increasing frequency by patients.Compared with photon therapy,proton therapy spares more critical structures due to its unique physics.The physical properties of a proton beam make it ideal for clinical applications.By modulating the Bragg peak of protons in energy and time,a conformal radiation dose with or without intensity modulation can be delivered to the target while sparing the surrounding normal tissues.Thus,proton therapy is ideal when organ preservation is a priority.However,protons are more sensitive to organ motion and anatomy changes compared with photons.In this article,we review practical issues of proton therapy,describe its image-guided treatment planning and delivery,discuss clinical outcome for cancer patients,and suggest challenges and the future development of proton therapy.