ASYMMETRIC SYNTHESIS OF THE DERIVATIVES OF (+)-1R,3R(3S), 5S-2,4,3-DIAZAPHOSPHABICYCLO [3.2.1] OCTANE

作     者：陈茹玉 刘立建 

作者机构：Institute of Elemento-Organic Chemistry Nankai University Tianjin 300071 PRC 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：1992年第35卷第2期

页      面：146-154页

核心收录：

学科分类：07[理学] 0703[理学-化学] 

主　　题：2 4 3-diazaphosphabicyclo [3.2.1] octane asymmetric synthesis chiral phosphorus atom diastereomer. 

摘      要： A new series of dextrorotatory derivatives of 1R,3RS,5S-1,8,8-trimethyl-2,4,3-diazaphosphabicyclo [3.2.1] octane with a newly formed chiral phosphorus atom has been prepared by an asymmetric reaction of (+)-cis-1R,3S-1,2,2-trimethyl-1,3-cyclopentadiamine with some thiophosphoryl dichlorides. The optically active products consisted of two unequal amounts of diastereomers,(1R, 3R, 5S) isomers and(1R, 3S, 5S) isomers. Two regioselective reactions took place when phenoxy thiophosphoryl dichloride and N,N-dialkylamino thiophosphoryl dichlorides were chosen as the reagents for the reaction. The content of (1R, 3R, 5S) isomers in the product was over 90% for the former and there were only (1R, 3S, 5S) isomers obtained for the latter.