Nanog and transcriptional networks in embryonic stem cell pluripotency

作     者：James A Thomson 

作者机构：PO Box 7365 WiCell Research Institute WI53715-1299 W153706-1509 1220 Capitol Court USAThe Genome Center of Wisconsin WI 53707-7365 425 Henry Mall The Wisconsin National Primate Research Center University of Wisconsin-Madison The Department of Anatomy WI 53706 470 N.Charter Street University of Wisconsin-Madison Medical School 

出 版 物：《Cell Research》 (细胞研究(英文版))

年 卷 期：2007年第17卷第1期

页      面：42-49页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 07[理学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 

主　　题：Nanog embryonic stem cell pluripotency transcription factor 

摘      要：Several extrinsic signals such as LIF,BMP and Wnt can support the self-renewal and pluripotency of embryonic stem(ES) cells through regulating thepluripotent genes. A unique homeobox transcription factor,Nanog,is one of the keydownstream effectors of these *** level of Nanog can maintain the mouse ES cell self-renewal indepen-dent of LIF and enable human ES cell growth without feeder *** addition to the external signal pathways,intrinsictranscription factors such as FoxD3,P53 and Oct4 are also involved in regulating the expression of ***,Nanog works together with other key pluripotent factors such as Oct4 and Sox2 to control a set of target genes that haveimportant functions in ES cell *** key factors form a regulatory network to support or limit each other’sexpression level,which maintains the properties of ES cells.