The Immunoregulatory Mechanisms of Kunmingshanhaitang Capsule On Treating Rat Adjuvant Arthritis
The Immunoregulatory Mechanisms of Kunmingshanhaitang Capsule On Treating Rat Adjuvant Arthritis出 版 物:《中国中医骨伤科杂志》 (Chinese Journal of Traditional Medical Traumatology & Orthopedics)
年 卷 期:2000年第6期
页 面:7-11页
学科分类:1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
主 题:Kunmingshanhaitang (KMSHT) capsule Adjuvant arthritis(AA) Cytokine Immunoregulation
摘 要:In this paper we studied the therapeutic effect of Kunmingshanhaitang (KMSHT) capsule on treating rat adjuvant arthritis(AA) and its immunoregulatory mechanisms. The results showed that KMSHT capsule could ameliorate rat arthritic symptoms. After treatment by KMSHT capsule, the activities of interleukin 1(IL 1)、tumor necrosis factor α(TNFα)、interleukin 6(IL 6) and interleukin 8(IL 8) in sera were diminished remarkably and inflammatory cytokine levers in joint fluids were reduced significantly . Cytokine production was significantly inhibited in peritoneal macrophages and splenic lymphocytes. ConA-induced splenocyte proliferative capacity was dramatically decreased in AA rats. Treatment with KMSHT capsule had no evident effect on splenocyte proliferation with AA control. In conclution ,KMSHT capsule has therapeutic efficacy in treatment of AA in rats. KMSHT capsule exerted its anti-inflammatory action via immunosuppression.