Dissection of voltage-gated sodium channels in developing cochlear sensory epithelia

作     者：You Zhou Fang-Hao Fang Zhi-Rui Liu Yong-Hua Ji 

作者机构：Laboratory of Neuropharmacology and Neurotoxicology ShanghaiUniversity Shanghai 200436 China 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2015年第6卷第6期

页      面：458-462页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1007[医学-药学(可授医学、理学学位)] 090403[农学-农药学(可授农学、理学学位）] 1002[医学-临床医学] 07[理学] 09[农学] 0904[农学-植物保护] 0703[理学-化学] 0836[工学-生物工程] 071002[理学-动物学] 

基　　金：The authors gratefully acknowledge Prof. LJn Chen for his interests in this study and providing valuable help with cochlear microdis- section. This study was supported by the National Basic Research Program （973 Program） （No. 2010CB529806）  partially by grants from National Natural Science Foundation of China （Grant No. 31171064） and Key Research Program of Science and Technology Commissions of Shanghai Municipality （11JC1404300  13DJ1 400300）. 

主　　题：Alternative Splice Hair Cell Editing Site Intracellular Loop Sensory Epithelium 

摘      要：Dear Editor Hair cells （HCs） clustered produce spontaneous spike n cochlear sensory epithelia and evoked action potentials during the developmental stage of auditory, which rely on many ion channels, such as Ca2＋ channels, K＋ channels and Na＋ channels （Housley et al., 2006; Marcotti et al., 2003）. As the dominant molecule acting in action potentials in most of excitable cells, Na＋ channels （VGSCs） were deemed to be indispensable in the spontaneous and evoked action po- tentials of HCs （Marcotti et al., 2003）.