New insights into pancreatic cancer stem cells
New insights into pancreatic cancer stem cells作者机构：Center for Cancer Prevention and Drug Development Department of Medicine Hematology-Oncology Section PC Stephenson Cancer Center University of Oklahoma Health Sciences Center Oklahoma City
出 版 物：《World Journal of Stem Cells》 (世界干细胞杂志（英文版）（电子版）)
年 卷 期：2015年第7卷第3期
页 面：547-555页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：In part by Kerley Cade Endowed Chair(Chinthalapally V Rao),University of Oklahoma Health Sciences Center in part support from the National Cancer Institute,No.5R03CA181584-02(Altaf Mohammed)
主 题：Pancreatic cancer Cancer stem cells DclK1 Lgr5 Prevention Treatment
摘 要：Pancreatic cancer(PC) has been one of the deadliest of all cancers, with almost uniform lethality despite aggressive treatment. Recently, there have been important advances in the molecular, pathological and biological understandingof pancreatic cancer. Even after the emergence of recent new targeted agents and the use of multiple therapeutic combinations, no treatment option is viable in patients with advanced cancer. Developing novel strategies to target progression of PC is of intense interest. A small population of pancreatic cancer stem cells(CSCs) has been found to be resistant to chemotherapy and radiation therapy. CSCs are believed to be responsible for tumor initiation, progression and metastasis. The CSC research has recently achieved much progress in a variety of solid tumors, including pancreatic cancer to some extent. This leads to focus on understanding the role of pancreatic CSCs. The focus on CSCs may offer new targets for prevention and treatment of this deadly cancer. We review the most salient developments in important areas of pancreatic CSCs. Here, we provide a review of current updates and new insights on the role of CSCs in pancreatic tumor progression with special emphasis on Dcl K1 and Lgr5, signaling pathways altered by CSCs, and the role of CSCs in prevention and treatment of PC.
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