Salvage liver transplantation in the treatment of hepatocellular carcinoma:A Meta-analysis

作     者：Hong-Yu Li Yong-Gang Wei Lv-Nan Yan Bo Li 

作者机构：Department of Liver and Vascular SurgeryCenter of Liver TransplantationWest China HospitalSichuan UniversityChengdu 610041Si-chuan ProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第19期

页      面：2415-2422页

核心收录：

学科分类：07[理学] 08[工学] 09[农学] 070104[理学-应用数学] 0901[农学-作物学] 0836[工学-生物工程] 090102[农学-作物遗传育种] 0701[理学-数学] 

主　　题：Salvage liver transplantation Primary livertransplantation Hepatocellular carcinoma Meta-analy-sis Survival rate 

摘      要：AIM:To evaluate survival and recurrence after salvage liver transplantation(SLT) for the treatment of hepatocellular carcinoma(HCC) compared with primary liver transplantation(PLT) using a ***:Literature on SLT versus PLT for the treatment of HCC published between 1966 and July 2011 was retrieved.A meta-analysis was conducted to estimate pooled survival and disease-free rates.A fixed or random-effect model was established to collect the ***:The differences in overall survival and disease-free survival rates at 1-year,3-year and 5-year survival rates were not statistically significant between SLT group and PLT group(P 0.05).After stratifying the various studies by donor source and Milan criteria,we found that:(1) Living donor liver transplantation recipients had significantly higher 1-year survival rate,lower 3-year and 5-year survival rates compared with deceased-donor liver transplantation(DDLT) *** in DDLT recipients they had better 1-year and 5-year disease-free survival rate in SLT group;and(2) No difference was seen in 1-year,3-year and 5-year survival rates between two groups who beyond Milan criteria at the time of liver ***:SLT can be effectively performed for patients with recurrence or deterioration of liver function after hepatectomy for *** does not increase the perioperative mortality and has a similar long-term survival rates compared to PLT.