Study on Lewis acid promoted condensation of allylalkoxysilanes with (-)-menthyl glyoxylate

作     者：CHEN, Yong-Jun HUANG, Liang WANG, Dong LI, Ji-Sheng Institute of Chemistry, Chinese Academy of Science, Beijing 100080, China 

作者机构：Institute of Chemistry Chinese Academy of Science Beijing 100080 China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：1994年第12卷第5期

页      面：440-448页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Project supported by the National Natural Science Foundation of China 

主　　题：Chiral glyoxylate allylalkoxysilane Lewis acid chelation asymmetric reaction. 

摘      要：Allylalkoxydimethylsilanes (2) condense with (-)-menthyl glyoxylate (3) in the presence of Lewis acid to give optically active menthyl 2-hydroxy-4-pentenoate (7) with optical purity of 31-42%. Factors affecting the yield and de of 7 have been examined. The stereochemistry of transition state of the reaction was discussed.