Effects　of　3，4－Dihydroxyacetophenone　on　Hypoxic　Vasoconstriction　in　Isolated　Pulmonary　and　Basilar　Arterial　Rings

作     者：王迪浔 邓洁 

作者机构：1. Department of Pathophysiology Tongji Medical University Wuhan 

出 版 物：《Journal of Huazhong University of Science and Technology(Medical Sciences)》 (华中科技大学学报（医学英德文版）)

年 卷 期：1994年第14卷第4期

页      面：252-256页

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

主　　题：pulmonary artery basilar artery hypoxia,3,4 Dihydroxyacetophenone 

摘      要：The effects of 3, 4-DHAP on hypoxic vasoconstriction response in pulmonary (PA) and basilar arterial(BA) rings of rabbits and their mechanism were compared in vitro.3,4-DHAP in different concentration (2.64×10-4,7.92×10-4,2.376×10-3mol/L) decreased the basal tone of PA rings by 32. 39±9.4 mg, 68. 96±26. 54 mg and 145. 60±58.07 mg respectively,while the tension of the BA rings was decreased by 13. 80±5. 08 mg,17.18±3.36 mg and 25. 00±4.02 mg *** PA rings it also decreased the percentage increase in tension induced by hypoxia(TIH%)from the control value 48. 82±5.75% to 10.02±3. 62%,2.14±0.96%, and 0.00% respectively, while in BA rings from 27.27±5.78% to 11. 23±2.71%,7.49±1. 62%, and 1.45±1.13% respectively. The effects of 3,4-DHAP on TIH% were partially blocked by indomethacin 10 M and L-NWE 10 *** results showed that 3, 4-DHAP can decrease the hypoxic pulmonary and basilar vasoconstriction in vitro. which can be partially inhibited by cyclooxygenase inhibitor and NO/EDRF inhibitor.