外源性睾酮对离体家兔阴茎海绵体的影响(英文)

作     者：Sahin YILDIRIM,Tijen UTKAN,Kemal YILDIRIM,Yusuf SARIOGLU 

作者机构：Department of Pharmacology Faculty of Medicine Cumhuriyet University 58140 Sivas Turkey Department of Pharmacology Faculty of Medicine Kocaeli University 41900 Kocaeli Turkey Department of Pharmacology Faculty of Medicine Cumhuriyet University 58140 Sivas Turkey Department of Pharmacology Faculty of Medicine Cumhuriyet University 58140 Sivas Turkey 

出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))

年 卷 期：2000年第21卷第2期

页      面：45-50页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Project supported by a grant from the Cumhuriyet University Research Fund (T-95/58) 

主　　题：睾酮 阴茎 电刺激 苯福林 硝普盐 卡巴胆碱 胍乙啶 阿托品 NG-硝基精氨酸甲酯 氯化钾 

摘      要：AIM: To study the effects of exogenous excess of testosterone on the constricting effect of phenylephrine and en-dothelium-dependent and -independent relaxing effects of different agonists in the corpus cavemosum penis (CCP). METHODS: Specimens of the CCP were obtained from rabbits testosterone for 1 and 2 months and untreated for 2 months after testosterone-treatment for 2 months. Preparations were mounted between two parallel platinum electrodes in organ baths. Responses to phenylephrine, car-bachol, and sodium nitroprusside were obtained by adding the reagent cumulatively to the bath. RESULTS: The phenylephrine-induced contractions were decreased with no change in agonist potency (pD2 value) after both 1 and 2 month testosterone-treatment and did not return to control values in corpus cavernosum obtained from rabbits untreated for 2 months after testosterone-treatment for 2 months. Testosterone treatment for 1 or 2 months increased the endothelium-dependent relaxations induced by carbachol and decrea