Proximal small intestinal bypass outperforms Roux-en-Y and jejunoileal bypass in glucose regulation in streptozotocin induced diabetic rats

作     者：Chi-Ying Xu Cai Tan Xin Luo Kun Yang Ren-Ran Wu Lei Lin Guan-Lei Liu Jin-Yuan Duan 

作者机构：Department of General SurgeryThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330000Jiangxi ProvinceChina Department of Women’s HealthJiangxi Maternal and Child Health HospitalNanchang 330000Jiangxi ProvinceChina 

出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志(英文))

年 卷 期：2025年第17卷第2期

页      面：237-246页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by National Natural Science Foundation of China,No.82360168 and No.81960154 Natural Science Foundation of Jiangxi Province,No.20212BAB206020 the Foundation of Health Commission of Jiangxi Province,No.SKJP220225830 

主　　题：Bariatric surgery Diabetes Glucose control Proximal small intestinal bypass Roux-en-Y gastric bypass Jejunoileal bypass 

摘      要：BACKGROUND The efficacy of various bariatric surgeries varies in reducing blood glucose *** the distinct mechanisms and anatomical alterations associated with each procedure,it is crucial to compare their glycemic control *** hypothesize that proximal small intestinal bypass(PSIB)is superior in blood glucose reduction over Roux-en-Y gastric bypass(RYGB)and jejunoileal bypass(JIB).AIM To compare the effectiveness of PSIB,RYGB,and JIB in lowering blood *** Rats with streptozotocin-induced diabetes were randomly divided into PSIB,RYGB,JIB,and sham-operated *** weight,food intake,fasting blood glucose level,oral glucose tolerance test,insulin tolerance test,liver enzymes,and blood lipids were *** Postoperatively,only the JIB group had a lower body weight compared to the sham *** food intake of the rats in all three surgical groups was significantly less than that in the sham *** blood glucose was reduced in all surgical groups and was lower in the PSIB group than in the RYGB and JIB *** tolerance and insulin sensitivity improved in all three surgical groups compared to the sham group,but the improvement appeared earliest in the PSIB *** six weeks postsurgery,the PSIB group showed a reduction in alanine transaminase levels and maintained a normal lipid *** PSIB demonstrated excellent hypoglycemic effects in the early postoperative period,and had better efficacy than RYGB and JIB.