Glabridin and gymnemic acid alleviates choroid structural change and choriocapillaris impairment in diabetic rat’s eyes

作     者：Udomlak Matsathit Manaras Komolkriengkrai Wipapan Khimmaktong 

作者机构：Department of Food Science and NutritionFaculty of Science and TechnologyPrince of Songkla UniversityPattani 94000Thailand Department of AnatomyDivision of Health and Applied SciencesFaculty of SciencePrince of Songkla UniversityHat Yai 90110SongkhlaThailand 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志(英文))

年 卷 期：2025年第16卷第3期

页      面：187-202页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by the Prince of Songkla University Research Fund No.SCI6302040S 

主　　题：Diabetes Choroid Gymnemic acid Glabridin Vascular endothelial growth factor Cluster of differentiation 31 Choriocapillaris 

摘      要：BACKGROUND Small blood vessels in the eyes are more susceptible to injury,which can lead to ***,since diabetic retinopathy is often a serious clinical condition,most of this study focuses on the vascular system of the *** part of this study,we looked at how gymnemic acid(from Gymnema sylvestre)and glabridin(from Glycyrrhiza glabra,or licorice)might help diabetic rats’choroid structural change and blood *** To explore the effects of glabridin and gymnemic acid on the structural changes of the choroidal layer and choriocapillaris as well as the expression of vascular endothelial growth factor(VEGF)and cluster of differentiation(CD)31 in diabetic rat’s *** The male Wistar rats were separated into five groups:The control group(control),the diabetic group(DM),the diabetic rats treated with glabridin 40 mg/kg body weight(DM+GB),the diabetic rats treated with gymnemic acid 400 mg/kg body weight(DM+GM),and the diabetic rats treated with glyburide 4 mg/kg body weight(DM+GR).RESULTS There was an increase in the thickness of both the choroid layer and the wall of the arteries in the DM.A decrease in vascularity and choroidal impairment was found in DM *** eight weeks of experimentation,the choroidal thickness increased,and the walls of choroid *** choroidal thickness in the DM+GB was 15.69±1.54μm,DM+GM was 14.84±1.31,and DM+GR groups was 16.45±1.15 when compared with DM group(27.22±2.05),the walls thickness of choroid arteries in the DM+GB was 10.23±1.11,DM+GM was 10.41±1.44,and DM+GR was 9.80±1.78 when compared with DM group(16.35±5.01),The expression of VEGF and CD31 was lower compared to the DM *** In diabetic choroidopathy,hyperglycemia and inflammation cause damage to the neurovascular unit and bloodretinal ***-VEGF treatments can slow or reverse the progression of the *** to current research findings,glabridin and gymnemic acid can reduce damage to the choroid,which is a factor t