Limited evidence to support demineralized bone matrix in foot and ankle surgical procedures:A systematic review

作     者：Hayden Hartman James J Butler Megan Calton Charles C Lin Samantha Rettig Jared C Tishelman Sebastian Krebsbach Grace W Randall John G Kennedy 

作者机构：Department of MedicineLincoln Memorial UniversityKnoxvilleTN 37752United States Department of Orthopedic SurgeryNYU Langone HealthNew YorkNY 10002United States Department of MedicineRoyal College of Surgeons in IrelandDublin D02 YN77LeinsterIreland 

出 版 物：《World Journal of Orthopedics》 (世界骨科杂志(英文))

年 卷 期：2025年第16卷第1期

页      面：57-67页

学科分类：0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 

主　　题：Demineralized bone matrix Allogenic bone graft osseous union Biological adjunct Systematic review Bone morphogenetic proteins Lower limb fusion Arthrodesis 

摘      要：BACKGROUND Demineralized bone matrix(DBM)is a commonly utilized allogenic bone graft substitute to promote osseous ***,little is known regarding outcomes following DBM utilization in foot and ankle surgical *** To evaluate the clinical and radiographic outcomes following DBM as a biological adjunct in foot and ankle surgical *** During May 2023,the PubMed,EMBASE and Cochrane library databases were systematically reviewed to identify clinical studies examining outcomes following DBM for the management of various foot and ankle *** regarding study characteristics,patient demographics,subjective clinical outcomes,radiological outcomes,complications,and failure rates were extracted and *** addition,the level of evidence(LOE)and quality of evidence(QOE)for each individual study was also *** studies were included in this *** In total,363 patients(397 ankles and feet)received DBM as part of their surgical procedure at a weighted mean follow-up time of 20.8±9.2 *** most common procedure performed was ankle arthrodesis in 94 patients(25.9%).Other procedures performed included hindfoot fusion,1st metatarsophalangeal joint arthrodesis,5th metatarsal intramedullary screw fixation,hallux valgus correction,osteochondral lesion of the talus repair and unicameral talar cyst *** osseous union rate in the ankle and hindfoot arthrodesis cohort,base of the 5th metatarsal cohort,and calcaneal fracture cohort was 85.6%,100%,and 100%,*** weighted mean visual analog scale in the osteochondral lesions of the talus cohort improved from a pre-operative score of 7.6±0.1 to a post-operative score of 0.4±*** overall complication rate was 27.2%,the most common of which was non-union(8.8%).There were 43 failures(10.8%)all of which warranted a further surgical *** This current systematic review demonstrated that the utilization of DBM in foot and ankle surgical proced