Risks of anti-Helicobacter therapy and long-term therapy with antisecretory drugs

作     者：Sergey M Kotelevets 

作者机构：Department of TherapyNorth Caucasus State AcademyCherkessk 369000Russia 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志(英文))

年 卷 期：2025年第31卷第4期

页      面：1-7页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Epidemiology Gastroesophageal reflux disease Proton pump inhibitor Potassium-competitive acid blocker Risk-benefit Gastroprotection Compensatory mecha-nisms Helicobacter pylori infection Sanogenesis 

摘      要：Helicobacter pylori(***)infection has a protective effect on gastroesophageal reflux disease(GERD).Both of these diseases have a very high incidence and *** a result,GERD often recurs after anti-Helicobacter *** problem of effective treatment of *** infection and GERD is that the main groups of drugs[proton pump inhibitors(PPIs)and potassium-competitive acid blockers]have the possibility of side effects with *** supposed side effects have no evidence in randomized controlled trials that comply with the principles of evidence-based *** changes in the gastric mucosa after long-term use of antisecretory drugs should be considered as compensatory mechanisms of *** greatest concern for doctors who treat patients with antisecretory drugs is the risk of gastric *** article presents an analysis of morphological and pathophysiological changes that occur after long-term use of antisecretory drugs(PPIs).Hypertrophy(hyperplasia)of G cells,enterochromaffin-like cells and possible fundic gland polyps(hyperplasia)are compensatory mechanisms of sanogenesis during long-term treatment with *** mechanisms are of primary importance for rehabilitation and prevention of complications in patients with GERD,non-steroidal anti-inflammatory drugsgastropathy and other diseases during long-term treatment with *** the pathophysiological and morphological mechanisms of compensation and adaptation,the mechanisms of sanogenesis and carcinogenesis will increase the number of indications for long-term use of PPIs with a high level of efficiency and safety of *** addition,understanding the pathophysiological and morphological mechanisms of compensation and adaptation,the mechanisms of sanogenesis will allow us to forecast the side effects of long-term use of potassium-competitive acid blockers.