A Self-assembled Nanomicelle for Realizing Tumor Photodynamic Therapy via Increasing Drug Accumulation and Prolonging Retention Time

作     者：AN Yaolong LI Zi-Heng WU Fu-Gen 安要龙;李子恒;吴富根

作者机构：State Key Laboratory of Digital Medical EngineeringKey Laboratory for Biomaterials and Devices of Jiangsu ProvinceSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 211189China 

出 版 物：《高等学校化学学报》 (Chemical Journal of Chinese Universities)

年 卷 期：2025年第46卷第1期

页      面：106-116页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 070304[理学-物理化学(含∶化学物理)] 08[工学] 0817[工学-化学工程与技术] 0703[理学-化学] 

基　　金：国家自然科学基金(批准号:82372127)资助 

主　　题：Photodynamic therapy Nanodrug Photosensitizer D-α-Tocopheryl polyethylene glycol 1000 succinate Cell apoptosis 

摘      要：A nanomicelle(denoted as TPGS/Ppa)was fabricated via the coassembly of the amphiphilic D-α-tocopheryl polyethylene glycol 1000 succinate(TPGS)and the hydrophobic photosensitizer pyropheophorbide a(Ppa)for photodynamic therapy(PDT).The obtained nanomicelle possessed a spherical structure with a diameter of(18.0±2.2)nm and a zeta potential of approximately -18 ***,the nanomicelle exhibited excellent photostability,biocompatibility,and phototoxicity,and could effectively reach the tumor region via the enhanced permeability and retention ***,it could be found that the TPGS/Ppa nanomicelle exhibited higher phototoxicity against 4T1 murine mammary cancer cells than free *** the 4T1 tumor-bearing mouse model,the nanomicelle showed an excellent antitumor therapeutic *** study develops a new type of photodynamic nanomicelle TPGS/Ppa,which can increase the accumulation of drugs and prolong their tumor retention time,providing a feasible strategy for realizing the delivery of small-molecule hydrophobic drugs and tumor PDT.