Polyphenols as Wnt/β-catenin pathway modulators: A promising strategy in clinical neurodegeneration

作     者：Biswajit Kumar Utpal Sajib Chandra Roy Mehrukh Zehravi Sherouk Hussein Sweilam A.Dinesh Raja M.Akiful Haque Chandan Nayak Senthilkumar Balakrishnan Laliteshwar Pratap Singh Saswati Panigrahi Mohammed Ali Alshehri Safia Obaidur Rab Najmus Sakib Minhaj Talha Bin Emran 

作者机构：Department of PharmacyFaculty of Health and Life SciencesDaffodil International UniversityDhakaBangladesh Department of PharmacyFaculty of PharmacyUniversity of DhakaDhakaBangladesh Department of Clinical PharmacyCollege of Dentistry and PharmacyBuraydah Private CollegesBuraydahSaudi Arabia Department of PharmacognosyCollege of PharmacyPrince Sattam Bin Abdulaziz UniversityAl-KharjSaudi Arabia Department of PharmacognosyFaculty of PharmacyEgyptian Russian UniversityCairoEgypt Department of PharmaceuticsKMCH College of PharmacyCoimbatoreIndia Department of Pharmaceutical AnalysisSchool of PharmacyAnurag UniversityHyderabadIndia Department of PharmaceuticsSchool of PharmacyArka Jain UniversityJharkhandIndia Department of PharmaceuticsJKKMMRF-Annai JKK Sampoorani Ammal College of PharmacyKomarapalayamNamakkalIndia Department of Pharmaceutical ChemistryNarayan Institute of PharmacyGopal Narayan Singh UniversitySasaramIndia Department of Pharmaceutical ChemistrySt.John Institute of Pharmacy and ResearchVevoorPalgharIndia Department of BiologyFaculty of ScienceUniversity of TabukTabukSaudi Arabia Department of Clinical Laboratory SciencesCollege of Applied Medical ScienceKing Khalid UniversityAbhaSaudi Arabia 

出 版 物：《Animal Models and Experimental Medicine》 (动物模型与实验医学(英文))

年 卷 期：2025年第8卷第2期

页      面：266-286页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：King Khalid University  KKU  (2/509/45) 

主　　题：neurodegenerative diseases neurological diseases polyphenols Wnt/β-catenin pathway 

摘      要：Polyphenols,a diverse group of naturally occurring compounds found in plants,have garnered significant attention for their potential therapeutic properties in treating neurodegenerative diseases(NDs).The Wnt/β-catenin(WβC)signaling pathway,a crucial player in neurogenesis,neuronal survival,and synaptic plasticity,is involved in several cellular mechanisms related to *** of this pathway is a hallmark in the development of various *** study explores multiple polyphenolic compounds,such as flavonoids,stilbenes,lignans,and phenolic acids,and their potential to protect the nervous *** provides a comprehensive analysis of their effects on the WβC pathway,elucidating their modes of *** study highlights the dual function of polyphenols in regulating and protecting the nervous system,providing reassurance about the research *** review provides a comprehensive analysis of the results obtained from both in vitro studies and in vivo research,shedding light on how these substances influence the various components of the *** focus is mainly on the molecular mechanisms that allow polyphenols to reduce oxidative stress,inflammation,and apoptotic processes,ultimately improving the function and survival of *** study aims to offer a thorough understanding of the potential of polyphenols in targeting the WβC signaling pathway,which could lead to the development of innovative therapeutic options for NDs.