Can Benzimidazole Resistance Undermine the Philippines’Success in Controlling and Eliminating Soil-Transmitted Helminth Infections?A Mini-Review
作者机构：Department of Tropical MedicineFaculty of MedicineKhon Kaen UniversityKhon KaenThailand WHO Collaborating Center for Research and Control of Opisthorchiasis(Southeast Asian Liver Fluke Disease)Tropical Disease Research CenterKhon Kaen UniversityKhon KaenThailand Department of Veterinary Paraclinical SciencesCollege of Veterinary MedicineUniversity of Southern MindanaoKabacanCotabatoPhilippines Department of ParasitologyCollege of Public HealthUniversity of the PhilippinesManilaPhilippines Neglected Tropical Diseases Study GroupNational Institutes of HealthUniversity of the PhilippinesManilaPhilippines Department of Clinical and Toxicological AnalysisFederal University of Minas GeraisBelo HorizonteBrazil.
出 版 物：《Infectious Microbes & Diseases》 (感染微生物与疾病（英文）)
年 卷 期：2024年第6卷第4期
页 面：163-169页
核心收录：
基 金：supported by the Postgraduate Scholarship for International Students of the Faculty of Medicine Khon Kaen University(No.2577/2019)to JCBT and the Fundamental Fund of Khon Kaen University and the National Science Research and Innovation Fund to SS.The funders had no role in study design data collection and analysis decision to publish or preparation of the manuscript
主 题：drug resistance neglected tropical diseases public health mass drug administration.
摘 要：Soil-transmitted helminth(STH)infections remain a significant global health burden,affecting over 1.5 billion people *** the Philippines,STH infections continue to be prevalent,despite ongoing control *** Integrated Helminth Control Program,whose cornerstone is the mass drug administration with benzimidazole drugs,has shown some success in reducing STH prevalence in the ***,the persistence of infection prevalence being above the national and global targets and the potential for benzimidazole resistance have raised concerns about the long-term sustainability of current control *** review examines the development of benzimidazole resistance in STH,focusing on the role of single nucleotide polymorphisms in theβ-tubulin isotype that alter the protein’s amino acid composition,thereby negatively affecting benzimidazole binding *** review discusses the epidemiology of STH infections in the Philippines,the implementation of the Integrated Helminth Control Program and the potential challenges posed by benzimidazole *** review highlights the need for further research to assess the occurrence of benzimidazole resistance in Philippine STH populations and to explore alternative control *** the mechanisms of benzimidazole resistance and developing effective countermeasures is crucial for achieving sustainable STH control and elimination in the Philippines.
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