Integrin β4 in Breast Cancer: A Focused Review

作     者：Zoya Salahuddin Shuhan Ying Emily Xie Aizhang Xu Xiaojing Ma Zoya Salahuddin;Shuhan Ying;Emily Xie;Aizhang Xu;Xiaojing Ma

作者机构：Weill Cornell Medicine-Qatar Doha Qatar Syosset High School Syosset New York Department of Mathematics University of California San Diego USA Department of Microbiology and Immunology Meyer Cancer Center Weill Cornell Medicine New York USA 

出 版 物：《Journal of Biosciences and Medicines》 (生物科学与医学（英文）)

年 卷 期：2024年第12卷第11期

页      面：255-272页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Integrins ITGB4 Prognosis EMT Angiogenesis Drug Resistance Cancer Therapy 

摘      要：Integrin β4 (ITGB4) is emerging as a pivotal player in breast cancer progression, particularly in aggressive and invasive subtypes such as triple-negative breast cancer (TNBC). This review broadly summarizes current research on ITGB4’s involvement in breast cancer, focusing on its role in metastasis, metabolic reprogramming, drug resistance, and immunoregulation that collectively influence tumor behavior with implications for the development of innovative and more efficacious therapeutic modalities.