Sensitizing effects of aradio－ and chemo－sensitizer，metronidazol amino acidum natrium（CMNa）
Sensitizing effects of a radio- and chemo-sensitizer, metronidazol amino acidum natrium(CMNa)出 版 物：《Journal of Medical Colleges of PLA(China)》 (中国人民解放军军医大学学报（英文版）)
年 卷 期：1994年第9卷第2期
页 面：93-97页
学科分类：1001[医学-基础医学(可授医学、理学学位)] 10[医学]
主 题：radiosensitizer chemosensitizer metronidazol amino acidum natrium (CMNa) esophageal neoplasms lung neoplasms human
摘 要：Radio-and chemo-sensitizing effects of a new sensitizer, metronidazol amino acidum natrium (CMNa), were studied by the methods of cell surviving fraction (in viiro), tumor growth delay (in vivo) and clinical observation. When the hypoxic V79 cells were exposed to γ-ray and CMNa, the cell surviving fraction decreased markedly as compared with radiation alone. The sensitizer enhancement ratio (SER) value was 1. 26-2. 32. When the mice bearing Lewis . B16 melanoma or EMT6 tumors were treated with single dose or fractionated radiation (with or without CMNa) or with antitumor agents (with or without CMNa) the tumor increasing velocity slowed down and the days of tumor growth delay increased significantly when CMNa was given *** 96 cases of lung cancer and 80 cases of esophageal cancer patients treated with routine chemotherapy or radiotherapy combined with CMNa, the percentage of CR+PR increased significantly. These results showed that CMNa may be an effective radio- and chemo-sensitizer.
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