Asymmetric Total Synthesis towards the Simplified Analogs of Antibiotic Elansolid A

作     者：Yang Shuai Wu Jie Wang Liangliang 杨帅;吴杰;汪亮亮

作者机构：State Key Laboratory of Phytochemistry and Plant Resources in West ChinaKunming Institute of BotanyChinese Academy of SciencesKunming 650201 University of Chinese Academy of SciencesBeijing 101408 

出 版 物：《有机化学》 (Chinese Journal of Organic Chemistry)

年 卷 期：2024年第44卷第7期

页      面：2350-2362页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Project supported by the High-Level Talent Program of Yunnan Province(No.Y93D321261) the Regional Development Program for Young Scholars,Chinese Academy of Sciences(CAS)(No.E323521311) the Science and Technology Department of Yunan Province(Nos.202305AH34005,202401AS070096) 

主　　题：asymmetric total synthesis coupling reaction simplified analog elansolid A 

摘      要：Natural product elansolid A belongs to one type of polyketide macrolactone with promising antibiotic ***-viously,the first total synthesis of elansolid A in 28 longest linear sequence(LLS)and 41 steps in total has been ***,the simplified analog of elansolid A,featured with a cyclohexyl-fused 19-memebered macrolactone,was proposed,and its asymmetric total synthesis based on a convergent strategy and key reactions exemplified by desymmetric alcoholysis of anhydride,Pd-catalyzed Stille coupling,Suzuki-Miyaura coupling as well as Mukaiyama macrolactonization was finished.