Regulation of mitophagy in ischemic brain injury

作     者：Yang Yuan Xiangnan Zhang Yanrong Zheng Zhong Chen 

作者机构：Department of PharmacologyKey Laboratory of Medical Neurobiology (Ministry of Health of China)College of Pharmaceutical SciencesZhejiang University 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2015年第31卷第4期

页      面：395-406页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (81373393 and 81273506) the Zhejiang Provincial Natural Science Foundation (LR15H310001) the Program for Zhejiang Provincial Leading Team of S&T Innovation Team (2011R50014) the Fundamental Research Funds for the Central Universities,China (2015FZA7018) 

主　　题：mitophagy ischemic brain injury mitochondria 

摘      要：The selective degradation of damaged or excessive mitochondria by autophagy is termed mitophagy. Mitophagy is crucial for mitochondrial quality control and has been implicated in several neurodegenerative disorders as well as in ischemic brain injury. Emerging evidence suggested that the role of mitophagy in cerebral ischemia may depend on different pathological processes. In particular, a neuroprotective role of mitophagy has been proposed, and the regulation of mitophagy seems to be important in cell survival. For these reasons, extensive investigations aimed to profile the mitophagy process and its underlying molecular mechanisms have been executed in recent years. In this review, we summarize the current knowledge regarding the mitophagy process and its role in cerebral ischemia, and focus on the pathological events and molecules that regulate mitophagy in ischemic brain injury.