Role of gap junctions in endothelium-derived hyperpolarizing factor-mediated vasodilatation in rat renal artery
Role of gap junctions in endothelium-derived hyperpolarizing factor-mediated vasodilatation in rat renal artery作者机构：Division of Biosciences Division of Biosciences School of Medical Sciences RMIT University Bundoora Victoria 3083 Australia School of Medical Sciences RMIT University Bundoora Victoria 3083 Australia
出 版 物：《Acta Pharmacologica Sinica》 (中国药理学报(英文版))
年 卷 期：2004年第8期
页 面：57-63页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学]
基 金：ThisworkwasfundedbyagrantbytheAustralianNationalHeartFoundation
主 题：
摘 要：AIM: To investigate the effect of cyclin-dependent kinase 5 (Cdk5) inhibitor roscovitine on the morphine antinociceptive tolerance development in rats. METHODS: Tail-flick test as pain threshold measurement and intrathecal injection techniques were used. RESULTS: Intrathecal roscovitine infusion alone produced an antinociceptive effect. Tolerance was induced by continuous intrathecal infusion of morphine 5μg/h for 5 d. Co administration of intrathecal roscovitine 1μg/h for 5 d enhanced the morphine antinociceptive effect in tolerant rats. It also caused a shift in the morphine antinociceptive doseCresponse curve to the left when co-administered with morphine during tolerance induction, and caused a 67 % reduction in the increase in the ED50 of morphine (dose producing 50 % of the maximum response). CONCLUSION: Cdk5 modulation is involved in the antinociceptive tolerance of morphine. Intrathecal roscovitine administration could attenuate this tolerance development.
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