enoscrotal extramammary Paget＇s disease： surgical Iechniques and follow-up experiences with thirty patients
enoscrotal extramammary Paget＇s disease： surgical Iechniques and follow-up experiences with thirty patients作者机构：Department of Urology and Andrology Ninth People's Hospital School ot Medicine Shanghai Jiaotong University Shanghai 200011 China
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2013年第15卷第4期
页 面：508-512,I0008,I0009页
核心收录：
学科分类：090603[农学-临床兽医学] 081203[工学-计算机应用技术] 08[工学] 09[农学] 0906[农学-兽医学] 0835[工学-软件工程] 0812[工学-计算机科学与技术（可授工学、理学学位）]
摘 要：To report the surgical management, complications and prognosis of patients with penoscrotal extramammary Paget＇s disease （EMPD） at different clinical stages. Between 2003 and 2008, a total of 30 male patients with penoscrotal EMPD were enrolled and evaluated. All enrolled subjects received frozen biopsy-guided local wide resection and immediate reconstruction. Patients were followed every 3 months postoperatively. Among the 30 patients who accepted and underwent frozen biopsy-guided local wide resection treatment and reconstruction, two （6.7%） cases exhibited positive margins, verified by pathological examination, and underwent re-excision after surgery. The technique of primary closure or an adjacent flap was used in 10 （33.3%） cases, split-thickness skin grafts were used in 15 （50%）, and an anterolateral thigh perforator flap was used in five cases （16.7%）. The postoperative complications were acceptable. The mean follow-up time was 64.9__.29.6 months. Of all 30 cases, 22 patients （73.3%） survived with no evidence of recurrence, four patients （13.3%） exhibited local recurrence, two patients （6.7%） exhibited both local recurrence and distant metastasis and the remaining two patients （6.7%） exhibited distant metastasis. Five patients died from metastasis or cachexia. Current surgical techniques, including primary closure, adjacent flaps, *** skin flaps and anterolateral thigh perforator flaps are able to reconstruct all types of defects with acceptable complications. Some patients with negative margins went on to exhibit local recurrence, potentially due to adnexal carcinoma or internal malignancy.
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