Synthesis of New Ligand 1,2-Bis{di[(R,R)-1,3,2-oxzaphosphlidine]phosphino}ethane with C_2-symmetric Axis and Application in Rh-catalyzed Asymmetric Hydrogenation

作     者：GONG Da-chun ZHOU Hua WEI Ping OUYANG Ping-kai 

作者机构：College of Chemistry and Life Science China Three Gorges University Yichang 443001 P. R. China College of Life Science and Pharmacy Nanfing University of Technology Nanfing 210009 P. R. China 

出 版 物：《Chemical Research in Chinese Universities》 (高等学校化学研究（英文版）)

年 卷 期：2007年第23卷第5期

页      面：544-548页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Supported by the National Basic Research Program of China(No.2003CB716000) 

主　　题：(R, R) -BDOPPE C2-Symmetry Asymmetric catalytic hydrogenation 

摘      要：New ligand 1,2-bis{di[（R,R）-1,3,2-oxzaphosphlidine]phosphino}ethane [（R,R）-BDOPPEs 1,2,3 and 4] with C2-symmetric axis and bearing nitrogen and oxygen were synthesized from readily available optically active amino *** complexes with these ligands were highly enantioselective catalysts for asymmetric hydrogenation of N-benzoyldehydroamino acid derivatives and α-functionalized ketones in 99%*** 98%e.e.,*** new class of（R,R）-BDOPPEs 1,2,3 and 4 gave much more effectivity and enantionselectivity than their corresponding non-C2-asymmetric aminophosphine phosphinite.