Studies on Antivirus Effects of Polysaccharides from Sargassum fusiforme in vitro

作     者：CEN,Ying-Zhou KHOO,Gaik-Ming WANG,Ling-Yun ZHANG,Ying 

作者机构：Department of Chemistry Jinan University Guangzhou 510632 Department of Chemistry Jinan University Guangzhou 510632 Department of Chemistry Jinan University Guangzhou 510632 Department of Chemistry Jinan University Guangzhou 510632 

出 版 物：《有机化学》 (Chinese Journal of Organic Chemistry)

年 卷 期：2004年第24卷第z1期

页      面：128-129页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Project supported by the National Natural Science Foundation of China (No. 2002A3050503) and the Natural Science Foundation of Guangdong Province(Nos. 2001-10-010401  2003-11-039213) 

主　　题：antiviral mechanism vero cells inhibitory effect MTT method 

摘      要： To assay antiviral effects of the polysaccharide and its separated products from Sargassumfusiforme on HSV-1 and CVB3 and their antiviral mechanism, the antiviral effects of all samples on HSV-1 and CVB3 and their cytotoxicity on vero cells were studied by CPE and MTT method. Antiviral mechanism of two samples was briefly studied by four different ways. The cytotoxicity of samples on vero cells was not detected (CC5000 μg/mL). All samples except PSJ had obviously HSV-1 inhibitory effect. Antiviral activities of them were increasingly strengthened with raising their *** activities of F1, F2 and F4 were better than that of ACV, and antiviral activities of all samples on CVB3 were better than ribavirin injection. Fi, F2 and F4 had remarkable anti-CVB3 activity. The experiment showed that polysaccharide was able to not only kill the above viruses directly but also restrain them by getting into cell or absorbing on cells.……