Quantitative measurement of the mechanical properties of human antibodies with sub-lO-nm resolution in a liquid environment
Quantitative measurement of the mechanical properties of human antibodies with sub-lO-nm resolution in a liquid environment作者机构：Center of Smart Interfaces Technische Universitot Darmstadt Alarich-Weiss-Str 10 64287 Darmstadt Germany Physics of Surfaces Institute of Materials Science Technische Universit~t Darmstadt Alarich-Weiss-Str. 16 64287 Darmstadt Germany
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2015年第8卷第6期
页 面：1987-1996页
核心收录：
学科分类：0810[工学-信息与通信工程] 090602[农学-预防兽医学] 0808[工学-电气工程] 0809[工学-电子科学与技术（可授工学、理学学位）] 08[工学] 09[农学] 0906[农学-兽医学] 0805[工学-材料科学与工程（可授工学、理学学位）] 081002[工学-信号与信息处理] 0702[理学-物理学]
主 题：atomic force microscopy structure and physicalproperties piconewton forces flexibility antibodies immunoglobulin
摘 要：The nanomechanical properties of single human immunoglobulin G and M antibodies were measured in a liquid environment using a fast force-volume technique with sub-10-nm spatial resolution. The ultrastructural details of these molecules were resolved in the images. Simultaneously, important physical properties, including elasticity, adhesion, and deformation were measured. The dimensions and adsorption of the immunoglobulin M antibodies onto the substrate indicated that they are highly by a low elastic stiffness （34 ± 10 MPa） flexible. The antibodies were characterized and high deformability （1.5 ± 0.5 nm）.
维普期刊数据库