阿尔茨海默病的自然史:对一个家族性队列进行症状出现前和症状发生时的纵向研究

作     者：Godbolt A.K. Cipolotti L. WattH. M.N.Rossor 王英鹏 

作者机构：Dementia Research Group Institute of Neurology Queen Square London WC1N 3BG United Kingdom Dr. 

出 版 物：《世界核心医学期刊文摘（神经病学分册）》 (Digest of the World Core Medical Journals:Clinical Neurology)

年 卷 期：2005年第1卷第3期

页      面：23-24页

学科分类：1002[医学-临床医学] 100203[医学-老年医学] 10[医学] 

主　　题：阿尔茨海默病 自然史 纵向研究 族性 神经心理学 智能缺陷 疾病晚期 神经生理学 进展过程 状态检测 

摘      要：Background: Knowledge of the evolution of cognitive deficits in Alzheimer dise ase is important for our understanding of disease progression. Previous reports, however, have either lacked detail or have not covered the presymptomatic stage s. Objective: To delineate the onset and progression of clinical and neuropsycho logical abnormalities in familial Alzheimer disease. Methods: Nineteen subjects with familial Alzheimer disease underwent serial clinical and neuropsychological assessments. Eight of these had undergone presymptomatic assessments. The follo w up period was 1 to 10 years (mean, 5 years). The relative timing of the occur rence of 3 markers of disease onset and progression (onset of symptoms, Mini Me ntal State Examination score ≤24, and impaired score on a range of neuropsychol ogical tests) were compared using the binomial exact test. Results: Neurological abnormalities were not prominent, although myoclonus appeared early in some. Mi ni Mental State Examination score was not sensitive to early disease. Memory an d general intelligence deficits appeared at an earlier stage, in some patients w hen pre symptomatic. Perceptual, naming, and especially spelling skills were pr eserved to a late stage. Conclusion: Familial Alzheimer disease may have a long prodromal phase of several years with subtle deficits initially of general intel ligence and memory, while spelling, naming, and perception are relatively preser ved until a late stage.