Danshen(Radix Salviae Miltiorrhizae)reverses renal injury induced by myocardial infarction

作     者：Lu Xiaomei Jin Yunan Ma Ling Du Lili 

作者机构：Department of PathophysiologyCollege of Basic MedicineChina Medical University 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2015年第35卷第3期

页      面：306-311页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：the Grants from the National Natural Science Foundation of China(Effects of Membrane-type Matrix Metalloproteinase 1 on Vascular Endothelial Cell Proliferation and Differentiation No.81100109) 

主　　题：Salvia Miltiorrhiza Myocardial infarction Reactive oxygen species 

摘      要：OBJECTIVE:To evaluate the protection of Danshen{Radix Salviae Miltiorrhizae)(SM) injection in myocardial infarction(Ml) induced renal ***:Forty male C57 mice were divided into control group,Ml group and SM *** Ml group,the left coronary artery was occluded for 8weeks;the same procedure was used for the SM group,with the additional step of SM(0.2 mL) administered intraperitoneally for 56 *** surgery and 8 weeks later,transthoracic echocardiography was performed and urine protein and albumin was *** the end of the time,all mice were killed and kidneys removed for reactive oxygen species(ROS) and fibrosis analysis,plasma was collected for blood urea nitrogen and serum creatinine ***:Ml slightly decreased renal function and increased production of ROS,accompanied with renal *** of SM reduced production of ROS and increased renal function,it also reduced renal ***:Ml plays a causal role in renal injury and SM exerts renal-protective effects,probably by its antioxidant activities.