子宫浆液性癌Her-2/neu过度表达的临床意义

作     者：Daz-Montes T.P Smith Sehdev A.E 李奎 

作者机构：Kelly Gynecologic Oncology Service Department of Gynecology and Obstetrics Johns Hopkins Medical Institutions 600 North Wolfe Street Phipps # 281 Baltimore MD 21287 United States 

出 版 物：《世界核心医学期刊文摘（妇产科学分册）》 (Core Journal in Obstetrics/Gynecology)

年 卷 期：2006年第2卷第5期

页      面：50-51页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：浆液性癌 Her-2/neu 手术分期 免疫组化法 肌层浸润 临床处理 生存分析 临床数据 回归模型 

摘      要：To evaluate the clinico-pathologic characteristics and survival outcome associated with overexpression of Her- 2/neu in patients with uterine serous carcinoma (USC). Methods. Twenty-five patients with a confirmed pathologic diagnosis of USC and available paraffin embedded tissue samples treated at the Johns Hopkins Medical Institutions from 1/1/1992 through 12/31/2000 were identified retrospectively. Her- 2/neu expression was evaluated by immunohistochemistry using HercepTest (DAKO). Clinical data were abstracted from medical records. Clinico-pathologic characteristics associated with Her- 2/neu overexpression like staging, histology, lymph-vascular space involvement, and myometrial invasion were evaluated using logistic regression analysis and Fisher’s exact test. Analyses of overall survival time were performed using the Kaplan-Meier method and Cox proportional hazards regression models. Results. Twelve (48% ) of the 25 USC cases demonstrated Her- 2/neu overexpression. There was a significant difference in Her- 2/- neu overexpression and surgical staging (81.8% vs. 28.6% , P = 0.01). Survival analysis according to primary tumor characteristics revealed that overexpression of Her- 2/neu was significantly associated with a worse survival outcome (HR = 6.58, 95% CI: 1.36- 31.89, P = 0.02). Conclusions. Her- 2/neu overexpression is associated with advanced surgical stage USC and poor survival outcome. These data may be useful in guiding the clinical management of patients with USC and have potential implications for the development of novel treatment strategies.