The role of BRCA 1 and BRCA2 in prostate cancer

作     者：Elena Castro Rosalind Eeles 

作者机构：Oncogenetics Team The Institute of Cancer Research Sutton SM2 5NG UK Academic Urology Unit The Royal Marsden NH Foundation Trust London SW3 6J J UK 

出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)

年 卷 期：2012年第14卷第3期

页      面：409-414,I0006页

核心收录：

学科分类：10[医学] 

基　　金：The European Community’s Seventh Framework Programme 

主　　题：BRCA1 BRCA2 prostate cancer 

摘      要：One of the strongest risk factors for prostate cancer is a family history of the disease. Germline mutations in the breast cancer predisposition gene 2 （BRCA2） are the genetic events known to date that confer the highest risk of prostate cancer （8.6-fold in men ≤ 65 years）. Although the role of BRCA2 and BRCA1 in prostate tumorigenesis remains unrevealed, deleterious mutations in both genes have been associated with more aggressive disease and poor clinical outcomes. The increasing incidence of prostate cancer worldwide supports the need for new methods to predict outcome and identify patients with potentially lethal forms of the disease. As we present here, BRCA germline mutations, mainly in the BRCA2gene, are one of those predictive factors. We will also discuss the implications of these mutations in the management of prostate cancer and hypothesize on the potential for the development of strategies for sooradic cases with similar characteristics.