Effects of plasma exchange combined with continuous renal replacement therapy on acute fatty liver of pregnancy

作     者：Cheng-Bo Yu Jia-Jia Chen Wei-Bo Du Ping Chen Jian-Rong Huang Yue-Mei Chen Hong-Cui Cao Lan-Juan Li 

作者机构：State Key Laboratory for Diagnosis and Treatment of Infectious Diseasesthe First Affiliated HospitalZhejiang University School of Medicine Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2014年第13卷第2期

页      面：179-183页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100211[医学-妇产科学] 10[医学] 

基　　金：supported by grants from the National Scientific and Technological Major Project of China (2011ZX10004-901 and 2013ZX10004904) the National Science and Technology Major Project (2012ZX10002006) the Scientific Research Fundation of the Education Department,Zhejiang Province (N20120081) 

主　　题：plasma exchange continuous renal replacement therapy acute fatty liver pregnancy liver failure 

摘      要：BACKGROUND: Acute fatty liver of pregnancy (AFLP) in the third trimester or early postpartum period can lead to fatal liver damage. Its traditional therapy is not very effective in facilitating hepatic recovery. The safety and effect of plasma exchange (PE)in combination with continuous renal replacement therapy(CRRT) (PE+CRRT) for AFLP still needs ***: Five AFLP patients with hepatic encephalopathy and renal failure were subjected to PE+CRRT in our department from 2007 to 2012. Their symptoms, physical signs and results were observed, and all relevant laboratory tests were compared before and after PE+***: All the 5 patients were well tolerated to the therapy. Four of them responded to the treatment and showed improvement in clinical symptoms/signs and laboratory results and they were cured and discharged home after the treatment One patient succeeded in bridging to transplantation for slowing down hepatic failure and its complications process after2 treatment sessions. Intensive care unit stay and hospital stay were 9.4 (range 5-18) and 25.0 days (range 11-42), ***: PE+CRRT is safe and effective and should be used immediately at the onset of hepatic encephalopathy and/or renal failure in patients with AFLP.