Advances in mammalian spermatogonial stem cell transplantation
Advances in mammalian spermatogonial stem cell transplantation作者机构：Faculty of Military Veterinary Quarter-Master University of PLA Changchun 130062 China Academy of Military Medical Sciences Beijing 100085 China Qian Wei Hospital of Jilin Province Changchun 130021 China The First Hospital of Jilin University Changchun 130021 China
出 版 物：《Progress in Natural Science:Materials International》 (自然科学进展·国际材料(英文))
年 卷 期：2004年第6期
页 面：5-9页
学科分类：10[医学]
基 金：SupportedbytheNationalNaturalScienceFoundationofChina (GrantNo .3 0 2 0 0 195 ) theProgramofScience&TechnologyDevelopmentofJilinProvince (GrantNo .2 0 0 10 5 5 5 )andtheMedicine&HealthScienceResearchFoundationofPLA (GrantNo.0 1MA2 0 4)
主 题：spermatogonial stem cell transplantation application.
摘 要：Spermatogonial stem cell (SSC) transplantation is a novel technique by which testicular cells from normal,transgenic or mutant donor are introduced into the seminiferous tubules of recipient testes through microinjection. Subsequently,donor SSCs survive,migrate,anchor and proliferate in the recipient testis,furthermore,initiate spermatogenesis and even produce sperms capable of fertilization. This technique provides a new approach for the researches of spermatogenesis mechanism,regeneration of spermatogenesis in sterile individuals and reproduction of transgenic animals. This review focuses on the methodological breakthroughs and highlights the recent findings that have substantially increased understanding of SSC biology. The article provides a comprehensive overview of this technique and its multiple applications in basic science and medicine. And the perspective direction of this field in the near future is proposed.
同方期刊数据库