儿科肾移植患者中的氧化应激与移植后高血压

作     者：CalòL.A. Dall'Amico R. Pagnin E. 朱新菊 

作者机构：Clinical and Experimental MedicineClinica Medica 4Pediatric Nephrology University of PadovaItaly Dr. 

出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)

年 卷 期：2006年第2卷第12期

页      面：39-40页

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：氧化应激 血压正常组 内皮功能紊乱 血红素加氧酶 抗氧化力 基因表达 脏器损害 研究设计 

摘      要：Objective:To test the hypothesis that oxidative stress signaling contributes to post-transplant endothelial dysfunction and hypertension in pediatric post-transplant hypertension. Study design:This study evaluated in 16 pediatric renal transplant patients,divided in two groups based on the presence of post transplant hypertension,the oxidative stress status measuring the gene expression (reverse transcription-polymerase chain reaction)of two major oxidative stress-related proteins,p22phox and heme oxygenase-1(HO-1). Total plasma antioxidant power(ELISA)was also evaluated. Results:Mononuclear cell p22phoxgene expression was higher in hypertensive patients compared with the normotensive group (0.91 ±0.06 vs 0.79 ±0.08 densitometric units,P 0.02),whereas HO-1 RNA production and total plasma antioxidant power were higher in the normotensive group (0.38 ±0.04 vs 0.20 ±0.11 d.u.,P 0.006,and 1189.35±145.75 vs 772.71 ±196.03 μmol/L,P 0.01,respectively).Conclusions:Oxidative stress is associated with post-transplant hypertension in hypertensive pediatric kidney-transplant patients,who therefore are at risk of oxidative stress-induced organ damage. They might benefit from treatments addressing not only hypertension but also oxidant-related complications.