Propofol's effect on the sciatic nerve Harmful or protective?

作     者：Yi Sun Xizhe Zhang Qi Zhou Yong’an Wang Yiwen Jiang Jian Cao 

作者机构：Chifeng Municipal Hospital 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2013年第8卷第27期

页      面：2520-2530页

核心收录：

学科分类：0710[理学-生物学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100602[医学-中西医结合临床] 10[医学] 

基　　金：financially supported by the Science and Technology Bureau of Inner Mongolia Autonomous Region No.Y2011024007 

主　　题：neural regeneration peripheral nerve injury propofol nuclear factor kappa B sciatic nerve injury inflammatory response nerve conduction immunosuppression myelin sheath grant-supportedpaper neuroregeneration 

摘      要：Propofol can inhibit the inflammatory response and reduce the secretion and harmful effects of as-trocyte-derived proinflammatory cytokines. In this study, after propofol was injected into the injured sciatic nerve of mice, nuclear factor kappa B expression in the L 4-6 segments of the spinal cord in the injured side was reduced, apoptosis was decreased, nerve myelin defects were al eviated, and the nerve conduction block was lessened. The experimental findings indicate that propofol inhibits the inflammatory and immune responses, decreases the expression of nuclear factor kappa B, and reduces apoptosis. These effects of propofol promote regeneration fol owing sciatic nerve injury.