Intravenous pantoprazole versus ranitidine for prevention of rebleeding after endoscopic hemostasis of bleeding peptic ulcers

作     者：Ping-IHsu Gin-HoLo Ching-ChuLo Chiun-KuLin Hoi-HungChan Chung-JenWu Chang-BihShie Pei-MinTsai Deng-ChyangWu Wen-MingWang Kwok-Hung Lai 

作者机构：Division of GastroenterologyDepartment of Internal MedicineKaohsiung Veterans General HospitalNational Yang-Ming University KaohsiungTaiwanChina Division of GastroenterologyDepartment of Internal MedicineKaohsiung Medical CollegeKaohsiungTaiwanChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2004年第10卷第24期

页      面：3666-3669页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Grants From the Kaohsiung Veterans General Hospital (VGHSU93-01) 

主　　题：静脉内疾病 相对作用 雷尼替丁 预防作用 消化性出血 内窥镜 止血法 消化性溃疡 

摘      要：AIM: The role of intravenous pantoprazole in treatment of patients with high-risk bleeding peptic ulcers following endoscopic hemostasis remains uncertain. We therefore conducted the pilot prospective randomized study to assess whether intravenous pantoprazole could improve the efficacy of H2-antagonist as an adjunct treatment following endoscopic injection therapy for bleeding ***: Patients with active bleeding ulcers or ulcers with major signs of recent bleeding were treated with distilled water injection. After hemostasis was achieved, they were randomly assigned to receive intravenous pantoprazole or ***: One hundred and two patients were enrolled in this prospective trial. Bleeding recurred in 2 patients (4%) in the pantoprazole group (n = 52), as compared with 8 (16%) in the ranitidine group (n = 50). The rebleeding rate was significantly lower in the pantoprazole group (P = 0.04).There were no statistically significant differences between the groups with regard to the need for emergency surgery (0% vs2%), transfusion requirements (4.9+5.9 vs5.7:1:6.8 units), hospital days (5.9+3.2 vs7.5:1:5.0 d) or mortality (2% vs 2%).CONCLUSION: Pantoprozole is superior to ranitidine as an adjunct treatment to endoscopic injection therapy in high-risk bleeding ulcers.