Capsaicin-sensitive afferentation represents an indifferent defensive pathway from eradication in patients with *** gastritis

作     者：Lilla Lakner András Dmtr Csaba Tóth Imre L Szabó gnes Meczker Rebeka Hajós László Kereskai Gyrgy Szekeres Zoltán Dbrnte Gyula Mózsik 

作者机构：Department of Medicine and GastroenterologyMarkusovszky Teaching Hospital First Department of MedicineMedical and Health CentreUniversity of Pécs Department of PathologyMarkusovszky Teaching Hospital Histopathology Ltd. Department of PathologyUniversity of Pécs 

出 版 物：《World Journal of Gastrointestinal Pharmacology and Therapeutics》 (世界胃肠药理与治疗学杂志（英文版）（电子版）)

年 卷 期：2011年第2卷第5期

页      面：36-41页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Grant Baross (REG_DD_KFI_09 CAPSATAB Hungary) 

主　　题：Capsaicin-sensitive afferentation Helico-bacter pylori Eradication therapy Afferent and efferent vagal nerves Transient potential vanilloid receptor 1 Calcitonin gene-related peptide Substance P 

摘      要：AIM:To study the role of capsaicin-sensitive afferent nerves in Helicobacter pylori (***) positive chronic gastritis before and after ***:Gastric biopsy samples were obtained from corpus and antrum mucosa of 20 healthy human subjects and 18 patients with *** positive chronic gastritis (n=18) before and after ***-tional gastric mucosal histology (and Warthin-Starry silver impregnation) and special histochemical examina-tions were carried *** for cap-saicin receptor (TRVP1),calcitonin gene-related peptide (CGRP) and substance P (SP) were carried out by the labeled polymer immunohistological method (Lab VisionCo.,USA) using polyclonal rabbit and rat monoclonal antibodies (Abcam Ltd.,UK).RESULTS:Eradication treatment was successful in 16 patients (89%).Seven patients (7/18,39%) re-mained with moderate complaints,meanwhile 11 pa-tients (11/28,61%) had no *** histological evaluation,normal gastric mucosa was detected in 4 patients after eradication treatment (4/18,22%),and moderate chronic gastritis could be seen in 14 (14/18,78%) *** immuno-staining for capsaicin receptor was seen in 35% (7/20) of controls,89% (16/18,P 0.05) of patients before and in 0% of patients (0/18,P 0.05) after *** ***:Distibution of TRVP1 and CGRP is altered during the development of *** positive chronic *** immune-staining for TRVP1,CGRP and SP rwemained unchanged before and after ***-lori eradication *** capsaicin-sensitive affer-entation is an independent from the eradication *** 6 wk time period might not be enough ti