Exposure to ambient air particulate matter and non-alcoholic fatty liver disease

作     者：Giovanni Tarantino Domenico Capone Carmine Finelli 

作者机构：Department of Clinical Medicine and Surgery Federico Ⅱ University Medical School of Naples INT "Fondazione Pascale" - Cancer Research Center of Mercogliano Unit of Clinical Pharmacology Department of Neuroscience Federico Ⅱ University Medical School of Naples Center of Obesity and Eating Disorders Stella Maris Mediterraneum Foundation C/da S. Lucia Chiaromonte 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2013年第19卷第25期

页      面：3951-3956页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Non-alcoholic fatty liver disease Particulate matter with aerodynamic diameters < 2.5 μm Cytochrome P-450 Reactive oxygen species 

摘      要：The present study was designed to alert the public opinion and policy makers on the supposed enhancing effects of exposure to ambient air particulate matter with aerodynamic diameters 2.5 mm (PM 2.5 ) on non-alcoholic fatty liver disease (NAFLD), the most common chronic liver disease in Western countries. For far too long literature data have been fixated on pulmonary diseases and/or cardiovascular disease, as consequence of particulate exposure, ignoring the link between the explosion of obesity with related syndromes such as NAFLD and air pollution, the worst characteristics of nowadays civilization. In order to delineate a clear picture of this major health problem, further studies should investigate whether and at what extent cigarette smoking and exposure to ambient air PM 2.5 impact the natural history of patients with obesity-related NAFLD,i.e. , development of non alcoholic steatohepatitis, disease characterized by a worse prognosis due its progression towards fibrosis and hepatocarcinoma.