Early termination of immune tolerance state of hepatitis B virus infection explains liver damage
Early termination of immune tolerance state of hepatitis B virus infection explains liver damage作者机构：Department of Hepa-tology Bangabandhu Sheikh Mujib Medical University Dhaka 1000 Bangladesh Department of Medical Sci-ences Toshiba General Hospital Tokyo140-0013 Japan Clinical Research Organization Dhaka 1213 Ban-gladesh Department of Anatomy and Embryol-ogy Ehime University Graduate School of Medicine Ehime 791-0295 Japan
出 版 物：《World Journal of Hepatology》 (世界肝病学杂志（英文版）（电子版）)
年 卷 期：2014年第6卷第8期
页 面：621-625页
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
主 题：Chronic hepatitis B Immune tolerance Early termination
摘 要：AIM: To assess an early termination of immune toler-ance state of chronic hepatitis B virus infection in Ban-gladesh and its clinical significance. METHODS: From a series of 167 treatment-naive chronic hepatitis B patients aged between 12 to 20 years(mean ± SD; 17.5 ± 2.8 years), percutaneous liver biopsies of 89 patients who were all hepatitis B e antigen negative at presentation were done. Of them, 81 were included in the study. They had persistently normal or raised serum alanine aminotransferase(ALT) values. A precore mutation(PCM) study was accom-plished in 8 patients who were randomly selected. RESULTS: Forty-four(53.7%) patients had significant necroinflammation(HAI-NI 7), while significant fi-brosis(HAI-F ≥ 3) was seen in 15(18.5%) patients. Serum ALT(cut off 42 U/L) was raised in 29(35.8%) patients, while low HBV DNA load( 105 copies/mL)was observed in 57(70.4%) patients. PCM was nega-tive in all 8 patients. CONCLUSION: This study indicates that the current concept of age-related immune tolerance state of HBV infection deserves further analyses in different popula-tion groups.
维普期刊数据库