Subharmonic and ultraharmonic emissions based on the nonlinear oscillation of encapsulated microbubbles in ultrasound contrast agents
Subharmonic and ultraharmonic emissions based on the nonlinear oscillation of encapsulated microbubbles in ultrasound contrast agents作者机构：State Key Lab of Modern Acoustics Institute of Acoustics Nanjing University Nanjing 210093 China
出 版 物：《Chinese Science Bulletin》 (CHINESE SCIENCE BULLETIN)
年 卷 期：2005年第50卷第18期
页 面：1975-1978页
核心收录：
学科分类：0810[工学-信息与通信工程] 08[工学] 081002[工学-信号与信息处理]
基 金：This work was supported by the National Natural Science Foundation of China(Grant Nos.10074033 and 10274032) the N ational Natural Science Foundation of Jiangsu Province(BK2004081) SRF for ROCS.SEM.and TWAS(No.03-390)
摘 要：Subharmonics or ultraharmonics provides better contrast-to-tissue ratio (CTR) than the fundamental or the second harmonics, having prospective application in medical diagnosis. In this paper, subharmonic and ultra-harmonic emissions are theoretically studied through nonlinear oscillation of encapsulated bubbles. The optimized frequencies for emissions of the subharmonics and ultra-harmonics are discussed. In addition, sound pressure de-pendences of the subharmonics and ultraharmonics are studied in theory as well as in measurement. Results reveal that the developments of both subharmonics and ultrahar-monics have the same trend, i.e. occurrence, growth and saturation, but the generation of ultraharmonic is a little earlier than that of subharmonic.
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