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Management of cholelithiasis in Italian children:A national multicenter study

Management of cholelithiasis in Italian children:A national multicenter study

作     者:Claudia Della Corte Diego Falchetti Gabriella Nebbia Marisa Calacoci Maria Pastore Ruggiero Francavilla Matilde Marcellini Pietro Vajro Raffaele Iorio 

作者机构:Department of PaediatricsUniversity of Naples "Federico Ⅱ"Via S. Pansini 5Naples 80131 Italy Department of Pediatric Surgery"Spedali Civili"Piazza Spedali Civili 1Brescia 25100Italy Department of Pediatrics ⅡFondazione IRCCS Ospedale Maggiore di MilanoVia F.Sforza 35Milan 20122Italy Department of PediatricsUniversity of FerraraVia Savonarola 944100 FerraraItaly Department of PediatricsIRCCS "Casa Sollievo della Sofferenza" Viale Cappuccini 1 San Giovanni Rotondo 71013Italy Department of PediatricsUniversity of Bari Piazza Giulio Cesare 11 Bari 70124 Italy Department of PediatricsOspedale "Bambin Gesù"Piazza S. Onofrio 4 Rome 00165Italy Department of Paediatrics University of Naples "Federico Ⅱ" Via S. Pansini 5 Naples 80131Italy Department of Paediatrics University of Naples"Federico Ⅱ" Via S.Pansini 5Naples 80131Italy 

出 版 物:《World Journal of Gastroenterology》 (世界胃肠病学杂志(英文版))

年 卷 期:2008年第14卷第9期

页      面:1383-1388页

核心收录:

学科分类:1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主  题:Pediatric cholelithiasis Ursodeoxycholic acid Laparoscopic cholecystectomy Gallstones Children 

摘      要:AIM:To evaluate the management of Italian children with cholelithiasis observed at Pediatric and Surgical Departments linked to Italian Society of Pediatric Gastroenterology Hepatology and Nutrition. METHODS: One-hundred-eighty children (90 males, median age at diagnosis 7.3 years; range, 0-18 years) with echographic evidence of cholelithiasis were enrolled in the study; the data were collected by an anonymous questionnaire sent to participating centers. RESULTS: One hundred seventeen patients were treated with ursodeoxycholic acid; in 8 children dissolution of gallstones was observed, but the cholelithiasis recurred in 3 of them. Sixty-five percent of symptomatic children treated became asymptomatic. Sixty-four patients were treated with cholecystectomy and in only 2 cases a postoperative complication was reported. Thirty- four children received no treatment and were followed with clinical and echographic controls; in no case thedevelopment of complications was reported. CONCLUSION: The therapeutic strategies were extremely heterogeneous. Ursodeoxycholic acid was ineffective in dissolution of gallstones but it had a positive effect on the symptoms. Laparoscopic cholecystectomy was confirmed to be an efficacy and safe treatment for pediatric gallstones.

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