ABH and Lewis antigen distributions in blood,saliva and gastric mucosa and H pylori infection in gastric ulcer patients
ABH and Lewis antigen distributions in blood,saliva and gastric mucosa and H pylori infection in gastric ulcer patients作者机构：Immunogenetics Endoscopy
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2006年第12卷第7期
页 面：1120-1124页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by the Secretaria Executiva de Ci ncia,Tecnologia e Meio Ambiente-SECTAM Coordena o de Aperfei oamento de Pessoal de Nivel Superior-CAPES.Co-first-authors:Luisa Caricio Martins,Tereza Cristina de Oliveira Corvelo
主 题：Helicobacter pylori Gastric ulcer ABH and Lewis blood groups
摘 要：AIM： TO investigate the ABH and Lewis antigen expression in erythrocytes, saliva and gastric epithelium, as well as the association between H pylori and the presence of gastric epithelial lesions. METHODS： The distribution of ABH and Lewis blood group antigens in erythrocytes, saliva and gastric mucosa of Hpylori-infected gastric ulcer patients was analyzed. Forty-two patients with gastric ulcer were studied, and fifty healthy individuals were used as control group. The blood group antigens were determined by direct hemagglutination, dot-ELISA and immunohistochemi- cal methods in erythrocytes, saliva and gastric mucosa specimens, respectively. Diagnosis for H pylori infection was performed by conventional optical microscopy and ELISA. RESULTS： A higher seroprevalence of IgG H pylori specific antibodies was observed in gastric ulcer patients （90%） compared to the control group （60%）. We observed a significant increase of phenotypes O, A2 and Lewis b in H pylori-infected patients. The expression of these antigens had progressive alterations in areas of ulcerous lesions and intestinal metaplasia. CONCLUSION： ABH and Lewis blood group antigens are a good indicator for cellular alterations in the gastric epithelium.
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