Quality of gastric ulcer healing evaluated by endoscopic ultrasonography

作     者：Jian-MinSi QianCao Jia-GuoWu 

作者机构：GastroenterologyLaboratoryInstituteofClinicalMedicineSirRunRunShawHospitalSchoolofMedicineZhejiangUniversityHangzhou310006ZhejiangProvinceChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2005年第11卷第22期

页      面：3461-3464页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by the Grant from the Eisai Human Health Care Company 

主　　题：Quality of ulcer healing Endoscopic ultrasono-graphy Gastric ulcer 

摘      要：AIM: To evaluate the quality of gastric ulcer healing after different antiulcer treatment by endoscopic ultrasonography(EUS).METHODS: The patients were divided into three groups, and received lansoprazole, amoxicillin and clarithromycinfor 1 wk. Then group A took lansoprazole combined with tepreton for 5 wk, group B took lansoprazole and group C took tepreton for 5 wk. Endoscopy and EUS were performed before and 6 wk after medication. RESULTS: There was no significant difference in cumulative healing rate to S stage between the groups (89%, 82%vs83%,P0.05). The rate of white scar formation was significantly higher in group A than in groups B and C (67%, 36%, 50%, P0.05). The average contraction rates of the width of ulcer crater, length of disrupted muscularis propria layer and hypoechoic area were higher in groupA than in groups B and C (0.792±0.090, 0.660±0.105 vs0.668±0.143, P0.05). The hypoechoic area disappeared in four cases of group A, one of group B and two of group C. The percentage of hypoechoic area disappearance was higher in group A than in the other two groups (44%, 9%vs 17%, P0.05). Gastric ulcer healing was better ingroup ***: The combined administration of proton pump inhibitors and mucosal protective agent can improve gastric ulcer healing.